Services
OUR SERVICES FOR CLIENTS
Tissue Processing
Tissue processing is crucial to the accurate study of tissue morphology and pathology, aiding diagnosis and research in various fields. Its main goal is to preserve tissue samples, so they can be thinly sectioned and stained for further microscopic examination. It involves a series of steps such as fixation, paraffination, embedding, sectioning, staining and coverslipping. Our laboratories are fully equipped to perform tissue processing all the way from an organism to a microscope, meanwhile, we can track the sample with a unique labeling system throughout its journey to ensure identification.
Microscopy
The Single Cell Center includes an extensive microscopy facility park that has been carefully selected to meet the various research, medical, and industrial project needs. Our collection of the latest technologies includes confocal scanning, slide screening, single cell cutting, digital light sheet microscopes, and high-content screening, providing an extensive selection of solutions to meet diverse requirements. With a commitment to leveraging cutting-edge instrumentation and fully automated systems, our facility stands prepared to accommodate high-volume demands and specialized research inquiries with utmost efficiency.
Image Analysis
With our advanced AI algorithms, we swiftly process large volumes of tissue images, ensuring rapid segmentation and profiling at the single-cell level. Leveraging multiple ultra-fast GPU clusters, our technology maximizes computational efficiency, enabling seamless integration into our BIAS software. Using BIAS, our technology streamlines workflows, empowering researchers with ready-to-use data for comprehensive analysis and insights into complex biological systems.
Single-cell Isolation
Our fully automated, single-cell laser microdissection system is controlled by AI-based solutions ensuring 24/7 operation. The total number of isolated cells can reach up to 10.000 cells a day. Single-cell samples isolated from tissue sections or cell cultures are compatible with various molecular downstream analyses such as genomics, transcriptomics, microarrays, metabolomics, next-generation sequencing, biochips, proteomics, and lipidomics.
Digital Pathology
is crucial for modern healthcare as it utilizes the digitization of histological slides, enabling easier storage, retrieval, and sharing of images. Our Single Cell Centre facilitates remote access to pathology experts, and through the implementation of state-of-the-art automatic image processing methods, fast and user-friendly access is provided to customizable analysis pathways. A custom-made Single-Cell Information Management System is available for easy sample and data handling.
Spatial single-cell omics
We utilize state-of-the-art single-cell omics in our workflow to gain deeper insights into complex molecular mechanisms. In the projects, our excellent collaboration partners perform a wide range of omics analyses.
Mass spectrometry facilities
The Matthias Mann group with two affiliations (Max Planck Institute of Biochemistry in Munich and Novo Nordisk Foundation Center for Protein Research in Copenhagen) has been a frontrunner in the technology and implementation of mass spectrometry-based proteomics working in close collaboration with world-leading mass spectrometry companies (Bruker Daltonik and Thermo Fisher). They developed an ultrasensitive mass spectrometry pipeline that can analyze true single-cell proteomes. This development, combined with our Ai-guided single-cell laser microdissection system, has established the Deep Visual Proteomics workflow that characterizes spatial proteomes at the single-cell level.
Functional Genomics Center Zürich Proteomics facility is an expert in proteomic techniques supporting the customers with the latest chromatography, mass spectrometry, and sample preparation techniques. Their low-input mass spectrometry methodologies can analyze single-cell proteomes using FFPE tissue samples.
Next generation sequencing facilities
Delta Bio 2000 Ltd. is a biotechnology-focused spin-off company in Szeged, established in collaboration with the BRC Szeged, specializing in the detection of new tumor markers and drug target proteins. Their single-cell diagnostics platform utilizes the newest genomic and transcriptomic methods to reveal molecular mechanisms at the single-cell level.
Functional Genomics Center in Zürich, Genomics unit offers state-of-the-art services in next-generation sequencing. They serve as a valuable resource for researchers, providing access to cutting-edge single-cell technologies. FGCZ provides extensive services and assistance for exploring the spatial aspects of gene expression. They give comprehensive solutions for the whole transcriptome and targeted spatial profiling analyses, starting with fresh frozen or FFPE tissue sections.
SeqOmics Biotechnology Ltd. was established by researchers to address the growing need for genomics and bioinformatics services. The company provides cutting-edge solutions for genome and whole transcriptome sequencing.
Lipidomics facility
HCEMM-BRC Single Cell Omics Advanced Core Facility is part of the recently established Hungarian Centre of Excellence for Molecular Medicine (HCEMM) research infrastructure. The facility provides a unique service that conducts comprehensive shotgun lipidomic analysis encompassing the identification and quantification of numerous lipid species. This methodology allows us to create a lipidomic map of the tissue section with a 80 μm resolution.
Contact Us
Phone Number
(+021) 123 – 456
(+021) 582 – 369
Location
Biological Research Centre
Temesvari krt. 62,
Szeged, Hungary
H-6726
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